Genesis may refer to:
- Book of Genesis, the first book of the biblical scriptures of both Judaism and Christianity – describing the creation of the Earth and of mankind
- Genesis (band), English rock band
- Genesis of the Daleks, Doctor Who Episode
- Sega Genesis, a 16-bit video game console also known as the Mega Drive. Popular for Sonic the Hedgehog.
- Terminator Genisys, a 2015 science fiction action film and fifth entry in the Terminator series